Table of Contents: Mac and Cheese Meatloaf Casserole
Mac and Cheese Meatloaf Casserole
The Ultimate Comfort Food Mashup You Need to Try
Imagine digging into a dish that combines two of the most beloved comfort foods—creamy, cheesy macaroni and juicy, flavorful meatloaf—all baked into one irresistible casserole. This Mac and Cheese Meatloaf Casserole is the ultimate weeknight dinner hero, delivering rich, cheesy goodness with every bite. Perfect for busy families, picky eaters, and anyone craving a hearty, satisfying meal, this recipe is a guaranteed crowd-pleaser.
Did you know that meatloaf dates back to ancient Rome, while mac and cheese became a staple in America thanks to Thomas Jefferson? Now, we’ve taken these classics and fused them into one epic dish that’s faster to make than traditional meatloaf and even more indulgent than regular mac and cheese. If you loved our Garlic Parmesan Chicken Pasta – The Ultimate Comfort Dish You’ll Love, you’ll adore this recipe—it’s just as easy but with a meaty twist!
Ready to make dinner unforgettable? Let’s dive in!
What is Mac and Cheese Meatloaf Casserole?
Ever wondered what happens when two comfort food legends collide? Meet the Mac and Cheese Meatloaf Casserole, a dish so decadent it should come with a happiness guarantee. Why settle for plain meatloaf when you can smother it in velvety mac and cheese? And why stop at mac and cheese when you can layer it over savory, well-seasoned ground beef?
Some say the way to a man’s heart is through his stomach, and this casserole proves it. One bite, and you’ll understand why this dish deserves a permanent spot in your dinner rotation. Whether you’re feeding a hungry family or just treating yourself, this recipe is pure comfort in every forkful.
So, are you ready to take your comfort food game to the next level? Let’s get cooking!
Why You’ll Love This Mac and Cheese Meatloaf Casserole
1. The Ultimate Comfort Food Mashup – This dish brings together the best of both worlds: tender, juicy meatloaf and creamy, cheesy macaroni. Every bite is a perfect balance of textures and flavors.
2. Budget-Friendly & Easy to Make – Skip the takeout! This casserole uses simple, affordable ingredients and comes together in under an hour. It’s a great way to stretch your grocery budget while still serving a delicious, filling meal.
3. Customizable & Family-Approved – Swap the cheeses, add veggies, or spice it up with jalapeños—this recipe is flexible enough to suit any taste. Plus, kids and adults alike will devour it!
If you enjoyed our Taco Pasta Recipe, you’ll love this just as much. Now, grab your ingredients and let’s make magic happen!
How to Make Mac and Cheese Meatloaf Casserole

Quick Overview
This casserole is easy, cheesy, and oh-so-satisfying. With just 30 minutes of prep and 30 minutes of baking, you’ll have a hearty meal that’s perfect for busy weeknights. The secret? A rich, creamy cheese sauce and perfectly seasoned meatloaf base.
Key Ingredients
– 1 lb ground beef (or turkey for a lighter option)
– 1 box (16 oz) elbow macaroni
– 2 cups shredded cheddar cheese (or a mix of mozzarella and gouda for extra creaminess)
– 1 cup milk
– ½ cup breadcrumbs
– 1 egg (to bind the meatloaf)
– 1 tsp garlic powder, 1 tsp onion powder, salt & pepper (for seasoning)
Step-by-Step Instructions
1. Preheat oven to 375°F (190°C).
2. Cook the macaroni according to package instructions, then drain.
3. Prepare the meatloaf mixture by combining ground beef, breadcrumbs, egg, and seasonings. Press into a greased casserole dish.
4. Make the cheese sauce by melting butter, whisking in flour, then slowly adding milk and shredded cheese until smooth.
5. Mix the sauce with cooked macaroni, then spread over the meatloaf layer.
6. Bake for 30 minutes until bubbly and golden.
7. Let cool slightly, then serve and enjoy!
What to Serve With Mac and Cheese Meatloaf Casserole
This dish is already a full meal, but pairing it with the right sides takes it to the next level. A crisp garden salad adds freshness, while garlic bread soaks up any extra cheese sauce. For a veggie boost, try roasted Brussels sprouts or steamed green beans. And if you’re feeling extra indulgent, a cold glass of sweet tea or sparkling lemonade balances the richness perfectly.
Top Tips for Perfecting Mac and Cheese Meatloaf Casserole
– Use freshly grated cheese for the smoothest sauce (pre-shredded cheese contains anti-caking agents).
– Let the casserole rest for 5-10 minutes before serving for cleaner slices.
– Add a crispy topping with extra breadcrumbs or crushed crackers for extra texture.
– Make it ahead by assembling the dish and refrigerating it overnight before baking.
Storing and Reheating Tips
– Refrigerate leftovers in an airtight container for up to 3 days.
– Reheat in the oven at 350°F (175°C) for best results (microwaving can make the pasta mushy).
– Freeze for up to 3 months—thaw overnight before reheating.
For more delicious casserole ideas, check out our Creamy Crockpot Chicken Alfredo: The Best Slow-Cooked Comfort Dish.
People Also Ask

How do you combine mac and cheese with meatloaf in a casserole?
Simply layer seasoned meatloaf mixture at the bottom of a baking dish, then top with creamy mac and cheese before baking. The two flavors meld together perfectly while keeping their distinct textures.
What cheese is best for mac and cheese meatloaf?
Sharp cheddar is classic, but a mix of mozzarella, gouda, or Monterey Jack adds extra creaminess. Avoid pre-shredded cheese for the smoothest sauce.
Is this a good family-friendly dinner?
Absolutely! Kids love the cheesy pasta, while adults appreciate the hearty meatloaf. It’s a guaranteed hit for picky eaters.
Can you make mac and cheese meatloaf casserole ahead of time?
Yes! Assemble the dish, cover, and refrigerate overnight. Bake as directed, adding a few extra minutes if needed.
Final Thoughts
This Mac and Cheese Meatloaf Casserole is comfort food at its finest—easy, cheesy, and packed with flavor. Whether it’s a busy weeknight or a cozy weekend meal, this dish delivers every time. Give it a try, and don’t forget to share your creations with us!
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Mac and Cheese Meatloaf Casserole
- Total Time: 1 hour
- Yield: 6 servings 1x
Description
A hearty comfort food classic that combines cheesy macaroni and savory meatloaf in one delicious casserole.
Ingredients
- 1 lb ground beef
- 1/2 cup breadcrumbs
- 1 egg
- 1/2 cup onion, finely chopped
- 2 cloves garlic, minced
- 1/2 cup milk
- 1 cup shredded cheddar cheese (for meatloaf)
- Salt and pepper to taste
- 2 cups elbow macaroni
- 2 cups shredded cheddar cheese (for topping)
- 2 tbsp butter
- 2 tbsp all-purpose flour
- 2 cups milk
- 1/2 tsp paprika
Instructions
- Preheat oven to 375°F (190°C).
- In a large bowl, combine ground beef, breadcrumbs, egg, onion, garlic, 1/2 cup milk, 1 cup cheddar cheese, salt, and pepper. Mix well.
- Press the meat mixture into a greased baking dish to form a flat meatloaf layer.
- Bake uncovered for 25 minutes.
- Meanwhile, cook macaroni according to package directions. Drain and set aside.
- In a saucepan, melt butter, whisk in flour, and cook for 1 minute.
- Gradually whisk in 2 cups milk until smooth, then stir in paprika and 2 cups shredded cheese until melted.
- Toss the cooked macaroni with the cheese sauce.
- Remove meatloaf from the oven and spread the mac and cheese evenly over the top.
- Sprinkle extra cheddar cheese on top and bake for an additional 15 minutes until bubbly and golden.
- Let cool for 5 minutes before slicing and serving.
Notes
For extra flavor, add a layer of ketchup or barbecue sauce over the meatloaf before topping with macaroni and cheese.
- Prep Time: 20 minutes
- Cook Time: 40 minutes
- Category: Casserole
- Method: Baked
- Cuisine: American
Nutrition
- Serving Size: 1 slice with mac and cheese
- Calories: 620
- Sugar: 5g
- Sodium: 880mg
- Fat: 32g
- Saturated Fat: 16g
- Unsaturated Fat: 14g
- Trans Fat: 1g
- Carbohydrates: 42g
- Fiber: 2g
- Protein: 38g
- Cholesterol: 135mg
Keywords: mac and cheese, meatloaf, casserole, comfort food